Ranked #1 LinkedIn HR Creator (Global), #2 Female Creator (US) | Positioning Companies & Founders to Attract Talent, Capital & Credibility | 100M+ Organic Reach | Ex-Amazon, Cognizant, Labcorp

200K+ LinkedIn & Newsletter Community 🐝 LinkedIn Growth Support, Talent Acquisition/Hiring & Brand Partnerships🐝 Neurodiversity Advocate 🐝

Hiring. Visibility. Credibility.

The three levers every founder, CEO, coach, or consultant needs to scale.
The problem? Most get them wrong.

That’s where I come in.

I built 𝐏𝐫𝐨𝐯𝐞𝐧 𝐏𝐚𝐭𝐭𝐞𝐫𝐧𝐬 to help seed to Series B startups, lean teams, and high-stake leaders attract the right talent, amplify their brand visibility, and build credibility that wins capital and clients.

What sets us apart?
We operate at the intersection of AI, recruitment, and brand strategy turning overlooked processes into growth systems.

Here’s what that looks like in numbers:
✔ 3,000+ hires placed globally across industries
✔ 250,000+ resumes reviewed with precision at scale
✔ 100M+ organic impressions without ad spend
✔ 150K+ community grown organically on LinkedIn
✔ 50K+ subscribers of our Li Newsletter: Incredible Edge
✔ Worked with enterprises like Amazon, Cognizant, Labcorp
✔ Partnered with unicorns like Atlan & Domino Data Lab
✔ Executed brand collabs with Lovable AI, Emergent AI, Gusto, Replit Agent 3, Gamma & GoPerfect
✔ Been named Favikon’s #1 HR Voice (Worldwide) and #2 Female Creator (US) - April'2025

But metrics are just the proof. The real outcome is this:

💡 Founders who save time and scale smarter.
💡 Executives who become visible authorities.
💡 Startups that attract capital and top talent on autopilot.

If you’re still struggling to hire right, stand out, or get noticed, it’s not because you lack potential.
It’s because you’re playing the wrong game.

My work is helping you change that.

📩 DM me or reach out: bookings@proven-patterns.com

Let’s build what they can’t ignore.

💜

Kumud Deepali Rudraraju, SHRM CP

I’ll never forget the person who gave me a chance when I had nothing impressive to show.

No big-name company on my resume.
No standout achievements.
No long list of credentials.

All I had was a positive attitude and a genuine willingness to learn.

At the time, I didn’t realize how rare that kind of opportunity was. Someone looked past the lack of experience and saw potential. They saw effort. They saw hunger. They saw someone who was willing to show up early, stay late, ask questions, make mistakes, and try again.

That single decision changed the direction of my career.

We often underestimate the power of being given a first shot. For many of us, that moment is the foundation everything else is built on. It’s where confidence starts. It’s where belief grows. It’s where skills are sharpened.

Experience matters, yes.
But mindset matters more.

You can teach systems.
You can train for skills.
You can guide someone through processes.

What you can’t easily teach is work ethic. Curiosity. Coachability. Gratitude for the opportunity.

And here’s something I’ve learned along the way:
When someone takes a chance on you early in your career, you carry that forward. You remember how it felt. And when you’re eventually in a position to hire, mentor, or lead, you look for potential in others the same way someone once looked at you.

That’s how real leadership compounds.

So if you’re early in your journey and feel overlooked, keep going. Keep learning. Keep improving. The right opportunity often comes disguised as a small one.
And if you’re in a position to give someone their first shot, don’t underestimate the impact you can have.

Sometimes belief is more powerful than experience.

If this resonates with you, share it and repost. 
And follow me for more reflections on leadership, growth, and building careers with intention.

Kumud Deepali R.

Kindness is not a weakness, it’s a leadership advantage.

In a world that often rewards speed, competition, and “winning at all costs,” kindness can feel underrated.

✔️ Kindness builds trust.
✔️ Kindness strengthens teams.
✔️ Kindness fuels collaboration.
✔️ Kindness creates leaders people want to follow.

Some of the strongest professionals I know are the ones who choose empathy even when it’s not the easiest option.

Let’s stop treating kindness like a liability.
It’s a skill.
A strategy.
A strength.

Imagine what our workplaces would look like if kindness was the standard, not the exception.

💬 How has kindness positively impacted your career, life or workplace?

I’ve been thinking a lot about who we choose to celebrate.

Every year, we see the same lists:
“30 Under 30.”
“40 Under 40.”
“Top Young Innovators.”

And don’t get me wrong, those achievements are impressive. Ambition deserves recognition. But here’s what we don’t talk about enough:
- The professional who had to start over at 52 after being laid off.
- The founder who rebuilt after a failed business.
- The parent who paused their career for a decade and came back stronger.
- The 60-year-old who finally earned their degree.
- The 70-year-old who published their first book after a lifetime of living, loving, losing, and learning.

That’s success too.

Not the fast-track version.

Not the highlight-reel version.

But the resilient version.

We tend to glorify speed. But longevity requires something different:
• Endurance
• Humility
• Perspective
• Emotional strength
• The courage to begin again

There’s something powerful about people who didn’t “make it early”, but made it anyway.
The ones with calloused hands and tender hearts.
The ones who stayed when quitting would have been easier.
The ones who kept showing up long after the applause faded.

Maybe we need fewer age-based accolades and more stories about resilience.
Because success isn’t about when you arrive.

It’s about whether you keep going.

If this resonates:
🔁 Repost to celebrate late bloomers and second acts
💾 Save this for the days you doubt your timeline
➕ Follow for more conversations about leadership, growth, and staying power

Who’s someone you admire who succeeded later in life or was it you? I’d love to hear their story.

Most people are using Copilot wrong.

They treat it like Google.

But Copilot isn’t a search engine.

It’s a productivity multiplier.

Here’s how to actually use Copilot across Microsoft 365 👇
🔵 Copilot in Word – Write faster, think sharper
 Use it to:
 • Draft documents from short prompts
 • Rewrite for clarity and tone
 • Summarize long reports into key takeaways
💡 Pro tip:
 “Summarize this document into 5 bullet points with action items.”
🟢 Copilot in Excel – Turn data into decisions
 Use it to:
 • Build charts, formulas, and pivot tables
 • Clean messy datasets
 • Highlight trends automatically
💡 Pro tip:
 Select your data and ask:
 “What’s driving this number?”
🟠 Copilot in PowerPoint – Build story-driven slides
 Use it to:
 • Create full decks from Word docs
 • Turn reports into visuals
 • Generate speaker notes instantly
💡 Pro tip:
 “Turn this report into a 7-slide executive summary.”
🟣 Copilot Chat – Your AI teammate
 Use it to:
 • Summarize meetings
 • Draft replies
 • Analyze PDFs and reports
 • Catch up on everything you missed
💡 Pro tip:
 “Summarize everything I missed this week.”

Stop asking Copilot to give you information.
Start asking it to help you think.

AI won’t replace professionals.
But professionals using AI will replace those who don’t.

If you're using Copilot at work, what’s your favorite prompt?

Hit the notification button and follow me on LinkedIn as I share the latest AI, career and workplace trends.

He woke up at 4 AM.

Worked as a trash collector to support his family.

Graduated with a 4.0 GPA.

And just got accepted into Harvard Law School.

Let that sink in.

No shortcuts.

No excuses.

No “perfect timing.”

Just discipline, sacrifice, and belief.

It’s easy to underestimate people based on their current situation. It’s harder to recognize the ambition they’re quietly building behind the scenes. This is what resilience looks like.

On LinkedIn, we often celebrate promotions, funding rounds, and titles.

But stories like this?

They remind us what real grit looks like.

Your starting point doesn’t define your finish line.
If you’re grinding in silence right now, keep going.

The early mornings. The long shifts. The unseen effort. It all compounds.
Success isn’t always loud.

Sometimes it starts in the dark at 4 AM.

💬 What’s one goal you’re working toward that people don’t see yet?

🔁 Repost to inspire someone.
💾 Save this for the days you feel like quitting.
➕ Follow for more stories that remind you what’s possible.

“Will you be my daddy… until I die?”

She was seven years old.
Sitting in a hospital bed.
Tubes in her nose.

And she asked a stranger,  a tattooed, intimidating-looking biker if he would pretend to be her father for however long she had left.

Mike was 58.
Tattoos down both arms.
The kind of man most kids are scared of at first glance.

Every Thursday, his motorcycle club volunteers at a children’s hospital, a tradition they started 15 years ago after one of their own experienced pediatric cancer in the family.

He’s read to dozens of sick kids.
But this time was different.
Her mother had left her at the hospital and never returned.

Halfway through a children’s book, she asked him if he had kids.
“I had a daughter,” he told her. “She passed away at sixteen.”
Then she asked quietly,
“Do you miss being a daddy?”
Every day.

She looked at him, far too wise for seven, and said she knew she was dying.
Then came the question:
“Will you be my daddy… until I die?”
He didn’t promise perfection.
He promised presence.
And just like that, he showed up.

The club rallied.
The hospital room filled with stuffed animals and laughter.
Thursdays became every day.

Six months passed.
Then nine.
Then a year.
Eighteen months later, she walked out of that hospital holding his hand.
Today she’s fifteen.
 
Cancer-free.

And she still calls him Daddy.

Every Thursday, they ride back to that same hospital, together to read to kids who are scared and hurting.

Here’s what she taught him:
• You don’t have to be perfect to show up.
• Love heals in ways medicine can’t explain.
• Sometimes the thing that feels like it will break you… rebuilds you instead.

He thought he was saving her.
But she saved him.

If this moved you, don’t just scroll.
💛 Comment “LOVE” if you believe showing up matters. Showup for someone this Valentine's Day. 
🔁 Repost to remind someone that presence changes lives.

Working with smart people is great.

Working with kind and humble people is next-level amazing.

In today’s world, talent is everywhere.

But character? That’s rare.

The smartest person in the room can elevate performance.

The kindest person in the room elevates everyone.

I’ve learned that the teams that truly thrive aren’t just high-performing, they’re high-trust.
• They share credit.
• They listen deeply.
• They assume positive intent.
• They win without ego.

Skills build businesses.
Character builds cultures.
As leaders, we should hire for both, but never compromise on humility.

💬 What qualities do you value most in the people you work with?
👉 Repost if you agree
👉 Follow for more reflections on work, leadership, and growth

📚AI gives you information. Books give you wisdom.

The Ultimate Reading Roadmap for Personal & Professional Growth
If you’re serious about leveling up in 2026, start here.

This collection breaks down must-read books into 9 key areas of life and career growth

💼 Productivity
- Atomic Habits by James Clear
- Deep Work by Cal Newport
- Do It Today by Darius Foroux
💰 Personal Finance
- The Millionaire Fastlane
- Psychology of Money
- Richest Man in Babylon
💬 Communication
- Talk Like TED
- How to Win Friends and Influence People
- Never Split the Difference
🧠 Human Behavior
- The 48 Laws of Power
- Influence by Robert Cialdini
- Surrounded by Idiots
🔥 Discipline
- Can’t Hurt Me
- Living with a SEAL
- Make Your Bed
💞 Relationships
- How to Be an Adult in Relationships
- Men Are from Mars, Women Are from Venus
- Closer to Love
💭 Philosophy
- Meditations by Marcus Aurelius
- Being and Nothingness
- What Are You Doing with Your Life?
🧩 Critical Thinking
- Think Again by Adam Grant
- Thinking, Fast and Slow
- The Art of Thinking Clearly
🆘 Self-Help
- The Magic of Thinking Big
- The Subtle Art of Not Giving a Fck*
- Mindset by Carol Dweck

If you could only pick one category to master in 2026, which one would it be and why? Share in the comments below. 

♻️ Repost to remind someone not to forget reading.

Everyone asks: “Which AI model should I actually use in 2026?”

Top 6 AI Models Ranked, based on real-world use, not hype.

Quick takeaways + where to learn each one:
🔹 Claude 4.5 → Best for deep reasoning, long documents, and professional work
📚 Learn more: https://lnkd.in/gRwxGbz4
🔹 ChatGPT-5.2 → Still the most versatile all-rounder for content, workflows, and automation
📚 Learn more: https://openai.com/chatgpt
🔹 Gemini 3 → Strong inside Google’s ecosystem, great for research + docs
📚 Learn more: https://lnkd.in/gnEymgGy
🔹 Perplexity → The fastest path to reliable, cited answers
📚 Learn more: https://www.perplexity.ai
🔹 Grok 4.1 → Unmatched for real-time trends and cultural context
📚 Learn more: https://x.ai
🔹 DeepSeek 3.2 → Open-source powerhouse for technical and engineering teams
📚 Learn more: https://www.deepseek.com

📌 There’s no single “best” model. There’s only the best model for your use case.

Pro tip: Most power users now rely on 2–3 models, not one.

Which AI are you using the most right now, and why? Drop it in the comments.

#ArtificialIntelligence #GenerativeAI #LLM #FutureOfWork #TechTrends #AItools #Productivity #2026

No matter how good you are, the wrong environment will make you question your worth.

I learned this the hard way.

A few years ago, I was in a role I had worked incredibly hard to earn. On paper, it looked perfect. Good title. Recognized company. Decent pay. From the outside, it seemed like I had “made it.”

But internally, I felt small.

Every meeting felt like a test. Every idea I shared was either ignored or picked apart. Feedback was rarely constructive. It was subtle, but constant. Over time, I stopped raising my hand. I started second guessing my instincts. I began over preparing for basic conversations because I assumed I would be challenged.

The worst part was not the criticism.

It was how I slowly started believing it.

I remember one evening sitting in my car after work, staring at the steering wheel longer than usual. I caught myself thinking, “Maybe I’m just not that good.” That thought scared me because I had never questioned my ability like that before.

Nothing about my skills had changed.

Nothing about my work ethic had changed.

The only thing that changed was the room I was in.

When you are in the wrong environment, even excellence feels average. Even confidence starts to shrink. Even effort feels invisible.

And when you are in the right environment, something completely different happens.
Your ideas are challenged, but with respect.
Your growth is supported, not threatened.
Your strengths are noticed.
Your weaknesses are coached, not weaponized.

I eventually made the decision to leave. It was not dramatic. No burned bridges. Just a quiet choice to bet on myself again.

The difference was immediate.

Same work ethic.
Same skill set.
Different culture.

Suddenly I was trusted with bigger projects. My voice carried weight. I felt energized instead of drained. It was not because I magically became better overnight. It was because I was finally in a place that valued what I brought to the table.

Here is what I wish someone had told me earlier:
If you constantly feel undervalued, it is not always a skill issue.
If you constantly feel unheard, it is not always a confidence issue.
If you constantly feel small, it is not always a competence issue.

Sometimes, it is simply misalignment.

We talk a lot about self improvement. We talk less about environment improvement.

If you are currently questioning your worth, pause before you question your ability. Ask yourself whether you are planted in the right soil.

Because even the strongest seed struggles in the wrong ground.

Have you ever experienced this shift when changing environments? I would love to hear your story.

Repost and like this post to share with your network, as someone might need this reminder and follow for more.

How will you choose to lift others today?

Life is too short to feel small at work.

You deserve to work somewhere you are:
✔ Accepted
✔ Respected
✔ Encouraged
✔ Inspired
✔ Empowered
✔ Valued

Yet too many professionals spend years in environments that slowly drain their confidence and creativity.

A great workplace doesn’t just pay you.
It uplifts you.
The right environment pushes you to grow, celebrates your ideas, and reminds you that your contribution matters.

And when people feel valued, they don’t just work harder, 
they show up with purpose.
And that’s when extraordinary things happen.

If you’re building a team, remember this:
People stay where they feel seen, supported, and respected.

If you’re building your career, remember this:
You’re allowed to choose spaces where you can thrive, not just survive.

What’s one thing that makes a workplace truly empowering for you?

Life’s three best teachers:
 💔 Heartbreaks
 💸 Empty pockets
 ❌ Failures

These moments hurt the most, yet they shape us the deepest.

They teach resilience, humility, and the true value of growth.

❤️ Heartbreaks remind us to value people who stay.
💰 Empty pockets teach us gratitude and resourcefulness.
📉 Failures push us to learn, evolve, and try again, smarter this time.

No book or degree can teach what pain, loss, or struggle can.
They don’t break us; they build us.

👉 What’s one lesson you learned from your toughest phase in life? Share it in the comments, your story might inspire someone today.

🔁 Repost this to uplift someone who might need a reminder that tough times create strong people.

Image Credit: The Positive Trader

Make it a habit to respect people, without knowing their qualifications, title, or position.
In today’s world, respect has become conditional.

We respect the CEO.
We respect the one with the big title.
We respect the one with the credentials, the awards, the followers.

But what about the person with none of those things, yet?
Real character is revealed in how you treat people
who cannot “do” anything for you.

The assistant.
The intern.
The new hire.
The quiet voice in the room.
The person without a LinkedIn headline that impresses you.

Reality Check:
Titles change.
Positions rotate.
Power shifts.
But character?
Character is permanent.

Some of the most successful leaders I’ve seen share one common trait:
They treat everyone with the same level of dignity.
Not because they have to.
But because it’s who they are.

Respect is not a response to status.
 It’s a reflection of values.

When you lead with respect:
• People feel safe to contribute
• Teams collaborate better
• Loyalty increases
• Culture strengthens
• Reputation grows organically

And here’s something even more powerful:
You never know who someone will become.
Today’s intern could be tomorrow’s investor.
Today’s junior employee could be tomorrow’s industry leader.
Today’s quiet observer could be your biggest advocate.

But even beyond opportunity, respect should never be transactional.
It should be habitual.
In rooms where ego is loud, humility stands out.
In environments where hierarchy dominates, kindness differentiates.

So the real question is:
Do you respect people only when their title impresses you?
Or do you respect people because your standards do?
The strongest leaders don’t command respect.
They demonstrate it first.

If this resonates with you, I’d love to know:
What does respect in the workplace mean to you?

Repost if you share the sentiment and follow for more.

Notice how the GPS never says
“you made a mistake.”
It simply says:
“Recalculating route.”
That’s a powerful way to look at life.

We often label our setbacks as failures; wrong decisions, wrong jobs, wrong paths.
But what if they’re not mistakes at all?
What if they’re simply course corrections?

Every challenge, delay, or unexpected turn is just life adjusting the route.
You’re still moving forward.
You’re still learning.
You’re still getting closer to where you’re meant to be.

So the next time things don’t go according to plan, remember:
You didn’t fail.
Life is just recalculating your route.

What’s one “detour” in your life that taught you something valuable?

If this resonated with you, follow for more insights on AI, growth, mindset, and career development, and feel free to repost so someone who needs to see this today doesn’t miss it.

Follow + Connect + Comment “Access to drive” if you want the complete clickable AI Agents roadmap.

Follow a roadmap to learn how to build AI agents. 
Most people jump between random tutorials.
A few actually master the ecosystem.
I found a complete AI Agents learning roadmap; all in one place:

🎥 Must-watch videos (LLMs, Agents, MCP, Scratch builds)
 🧠 Top GitHub repos (Microsoft, Anthropic, GenAI frameworks)
 📘 Practical guides (OpenAI, Google, Claude best practices)
 📚 Books from Nicole Koenigstein, Michael Alibada, Kyle Stratis & more
 📄 Foundational papers (ReAct, Toolformer, Tree of Thoughts, RAG)
 🎓 Courses (HuggingFace, MCP with Anthropic)

Whether you're:
 • A beginner starting with LLMs
 • A developer building production agents
 • Or an AI engineer diving into MCP & advanced reasoning
This list covers it.

AI Agents are not the future.
They’re the current leverage layer of software.
The builders who understand:
LLMs + Tools + Memory + Evaluation
 …will define the next decade.

If you want access to the complete clickable resource drive:
👉 Follow me
👉 Connect with me
👉 Send a note saying: “Access to drive”

I’ll share the full curated list with all links.

Let’s build smarter systems. 

Image Credit: Respective Owner

How Do You Actually Get AI ROI in 30 Days?

“30 days” doesn’t mean full enterprise transformation.

It means:
 👉 A validated use case
 👉 A working pilot
 👉 Measurable early impact

Here’s what a realistic 30-day sprint looks like:
🗓️ Week 1: Clarity & Baseline (Days 1–7)
Direction before development
✔ Define one high-impact use case
✔ Align stakeholders on expected outcome
✔ Identify measurable KPIs
✔ Gather usable data
✔ Establish baseline metrics
🎯 Outcome: Clear problem. Clear success criteria. Clear starting point.

🗓️ Week 2: Prototype & Test (Days 8–14)
Build fast, not perfect
✔ Develop a lean prototype
✔ Test with real data
✔ Identify gaps & risks
✔ Iterate quickly
🎯 Outcome: Early proof of value.

🗓️ Week 3: Pilot Deployment (Days 15–21)
Validate in the real world
✔ Deploy in a controlled environment
✔ Monitor performance vs. baseline
✔ Collect user feedback
✔ Refine workflows
🎯 Outcome: Business validation, not just a demo.

🗓️ Week 4: Measure & Prepare to Scale (Days 22–30)
Turn performance into ROI
✔ Quantify improvement (time, cost, revenue, efficiency)
✔ Document impact
✔ Build adoption plan
✔ Executive go/no-go decision
🎯 Outcome: A clear ROI case + roadmap to scale.

AI ROI doesn’t come from building the most advanced model.
It comes from:
• Picking the right problem
• Moving fast
• Measuring properly
• Prioritizing adoption

If your organization had to implement ONE AI use case in 30 days…
What would it be?

If this breakdown was helpful:
 👍 Like
 🔁 Repost on LinkedIn to help your network
 ➕ Follow for practical AI execution frameworks (no hype, just results)

One opportunity can change your entire life.
Not five.
Not fifty.
Just one.

One conversation.
One introduction.
One meeting where you almost did not show up.
One message you almost did not send.

The problem is, opportunities rarely look like opportunities in the beginning.
They look like small rooms.
They look like unpaid work.
They look like early mornings and late nights.
They look like rejection.
They look like being overlooked.

Most people quit in the season right before things change.
They stop posting because engagement is low.
They stop applying because no one responds.
They stop building because growth feels slow.
They stop showing up because no one is clapping yet.

But the breakthrough does not announce itself.
It shows up quietly and asks, “Are you still here?”

I know people whose careers changed because they attended an event they did not feel like going to.
I know founders who met their biggest client through a random introduction.
I know creators who went viral on a random Tuesday after years of consistency.

From the outside, it looks like luck.
From the inside, it looks like discipline.

You cannot control when the opportunity arrives.
You can control whether you are ready when it does.
That means:

Keep improving your skills even when no one is watching.
Keep building relationships even when there is no immediate payoff.
Keep creating even when the numbers are small.
Keep learning even when it feels repetitive.

And show up.
Show up tired.
Show up uncertain.
Show up before you feel ready.
Show up when it feels pointless.

Just keep showing up.

The version of you that almost quit will thank the version of you that did not.

If this message hit you at the right time, repost it to remind someone else not to give up.
Follow me for more reminders that consistency beats talent when talent stops trying.

David Fajgenbaum, MD, MBA, MSc, is co-Founder & President of Every Cure and a physician-scientist at the University of Pennsylvania, where he is one of the youngest faculty members ever to receive tenure at Penn Medicine. He is also the national bestselling author of Chasing My Cure: A Doctor’s Race to Turn Hope Into Action, which is being adapted into a film by Forrest Gump producer Wendy Finerman. 

During medical school, Fajgenbaum discovered a treatment that saved his own life and founded the Castleman Disease Collaborative Network.  He has advanced 13 more repurposed treatments for cancers and rare diseases and co-founded Every Cure to unlock more hidden cures from existing medicines which has received over $100M from ARPA-H and TED’s Audacious Project. He also serves on the Board of Directors for the Reagan-Udall Foundation for the FDA. 

One of the youngest recipients of multiple top NIH and FDA grants, Fajgenbaum has authored over 100 scientific papers in leading journals, including The New England Journal of Medicine, The Lancet, and The Journal of Clinical Investigation. He has been profiled by The New York Times, Good Morning America, TODAY, and Forbes 30 Under 30 and has received numerous honors, including the 2016 Atlas Award alongside then VP Joe Biden, 2022 NDRI Service to Science Award alongside Nobel Laureates Katalin Kariko and Drew Weissman, 2023 Philadelphia Citizen of the Year Award, and selection to the 2025 TIME100 Health list of the world’s most influential people in health. Fajgenbaum earned a BS from Georgetown University, MSc from the University of Oxford, MD from the University of Pennsylvania, and MBA from The Wharton School.

David Fajgenbaum

It was such an honor for me to speak at the Foundation for the National Institutes of Health’s event celebrating the 20th anniversary of their Biomarker Consortium. The scientific progress and patient impact that they have made over these 20 years has been incredible, and I am so impressed by Julie Gerberding’s leadership of this important foundation! 

I loved being able to share about Every Cure’s work and the potential for drug repurposing to save lives. Here’s to the next 20 years of impact!

David Fajgenbaum, MD, MBA, MSc

Physician-Scientist @ UPenn | Co-Founder & President @ Every Cure | Bestselling Author, Chasing My Cure | TIME100 Health | 2025 TED

Foundation for the National Institutes of Health

View company: Foundation for the National Institutes of Health

David Fajgenbaum, MD, MBA, MSc, Co-Founder & President of Every Cure, highlighted his personal journey navigating Castleman disease — adding his insights into how we can use biomarkers to drive precision medicine and drug repurposing for other diseases. Many thanks to Dr. Fajgenbaum for sharing his inspiring story.

#biomarkers #BiomarkersConsortium #regulatoryscience #biomarkerscience #BCSymposium

We just published a paper using CRISPR to engineer a mouse with my exact disease-causing mutation!

Back in 2016, my lab began editing mouse genomes with CRISPR. Last month in Blood Advances, we described a model where we inserted my mutation into a gene called CABIN1 — and the mice developed features of Castleman disease. For the first time, we now have a living system that closely mirrors the condition.

This allows us to test medicines originally built for other diseases to see if they relieve symptoms — a powerful example of how modern biology can accelerate drug repurposing and bring treatments to patients faster.

None of this would be possible without an incredibly generous anonymous donor and the remarkable Penn Medicine, University of Pennsylvania Health System researchers, including Taku Kambayashi and Dorottya Laczkó, who pushed this work forward.

Learn more about the paper by clicking the link below
https://lnkd.in/e9MBg_WP

I'm thrilled to share this video highlighting Every Cure Chief Scientific Officer Matt Goddeeris!

It has been so incredible to witness the impact that he’s had on our mission, the way he works with everyone across our team, and his commitment to advancing rigorous science towards patient impact.

Today we are excited to feature our Chief Scientific Officer Matt Goddeeris!

Matt Goddeeris, PhD, leverages his expertise as a cell biologist and drug hunter to drive therapeutic innovation. With over a decade of experience building teams around groundbreaking concepts, he has advanced three novel small molecules to IND across a range therapeutic areas to treat rare disease. 

Previous to Every Cure, Matt leverage AI/ML to fuel discovery at Cellarity and helped advance ELX-02 in cystic fibrosis and cystinosis clinical trials at Eloxx Pharmaceuticals. Matt earned his Bachelors of Science degree in Biochemistry at Michigan State University and PhD in Cell and Developmental Biology at Duke University.

I loved being on this podcast with my friend and AI-pioneering physician-scientist, Sean Khozin! I loved having the opportunity to chat with him about #chasingmycure, drug repurposing, “computational pharmacophenomics”, and the important work that the CEO Roundtable on Cancer and Every Cure are doing to save and improve lives! (And the first 4 minutes are a cool AI-created synopsis).

What happens when a physician becomes the principal investigator of his own disease?

In the latest episode of Precision Signals, our CEO Sean Khozin opens what he calls a deeply personal conversation with David Fajgenbaum, MD, MBA, MSc. A former Division I quarterback at Georgetown University in peak physical condition, David had already endured profound loss at 19 when his mother died of brain cancer. He promised her he would dedicate his life to finding treatments for patients like her. Years later, as a third-year medical student at the University of Pennsylvania School of Medicine, his own liver, kidneys, and bone marrow began failing within weeks. He was admitted to the ICU and read his last rites five times, receiving a diagnosis of idiopathic multicentric Castleman disease, a rare and life-threatening inflammatory disorder.

What followed was not only a fight for survival but a shift in perspective. David realized that biomedical knowledge does not automatically organize itself around patients. He later called this the “Santa Claus realization”: there is no coordinated system ensuring that every disease is strategically pursued. Refusing to accept fragmentation as fate, he banked his own blood, ran proteomic analyses, and identified an mTOR pathway signal that led to a decades-old transplant drug never before used for his condition. 

He has now been in remission for more than a decade.

From that experience came infrastructure. David founded the Castleman Disease Collaborative Network, uniting physicians and researchers in more than 60 countries, and later co-founded Every Cure, a nonprofit using AI to evaluate every approved drug against every known human disease. 

This episode moves from one life on the brink to an examination of how cures are truly discovered, where markets fail, and how fragmentation threatens health outcomes. It is ultimately a story of resilience and a challenge to rethink precision medicine not as a promise confined to single breakthroughs, but as a disciplined, coordinated effort across the full landscape of human disease.

https://lnkd.in/eyxA3qF6

Open video: Episode 8 | David Fajgenbaum: Surviving Castleman Disease and Reinventing Drug Discovery with AI on youtu.be

Episode 8 | David Fajgenbaum: Surviving Castleman Disease and Reinventing Drug Discovery with AI

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David Fajgenbaum

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The Battle

Kumud Deepali Rudraraju, SHRM CP

David Fajgenbaum

Followers

Posts

Engagements

Likes

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