Think10

www.Think-10.com is a life science business consultancy, a personal coaching and team development to all businesses and a service to the pharmaceutical industry to facilitate change,

Melanie Lee PhD, CBE, FMedSci, DSc(Hons)

LifeArc

Chief Executive Officer

Principal CEO

BTGplc

BTG plc is a fast growing exciting Interventional Medicine company - on the international stage with it's HQ in London. We have device and drug combination products in the Interventional vascular and oncology space and have recently entered the Interventional Pulmonary area with the acquisition of PneuMRx and their innovative coiled device to treat emphysema patients. Interventional medicine routes to the market place in the hands of skilled physicians is likely to be relevant to many of the emerging new modalities in the pipelines of our innovative biotechs today.

Chief Scientific Officer

NightstaRx Ltd

NightstaRx is a Syncona backed company established to pursue the gene therapy treatment of Choroideremia to prevent the deterioration of eyesight in patients with this X-linked disease which causes loss of sight during the mid 40-50 years of life. Early clinical studies by Robert MacLaren have shown promising efficacy and good safety. The therapy for this indication is to replace the faulty REP1 gene in the eye with a functioning copy in an AAV vector. NightstaRx aims to gain regulatory approval for this therapy with ensuring GMP of the product and agreeing the pivotal clinical path. Www.nightstarx.co.uk

NED (was Founding CEO during 2014)

Syntaxin Ltd

Syntaxin was a successful biotech spun out of the HPA that was developed by myself and my management team, with the help if course of our excellent scientists, to a stage for acquisition to ensure the further investment in the recombinant botulinum toxin technology. Ipsen acquired Syntaxin in July 2013 and the site continues as Ipsen's centre for toxin engineering, complementing well the Ipsen expertise in toxin biology. I left Syntaxin with the acquisition and now work through Think10 as I discuss new opportunities.

Chief Executive officer

EVP and President UCB NewMedicines

Breast Cancer Haven

Angel

Applied Genomics Link Scheme

Working to award funds to innovate collaborative programmes between strong academic groups and small companies.

Chairman

Celltech

EVP R&D, Celltech

Glaxo

Unit Head

I'm a passionate leader dedicated to driving innovation and positive impact in the life sciences industry.🔬

Throughout my career, I have championed the translation of scientific knowledge into impactful healthcare solutions and am passionate about fostering an environment that encourages multidisciplinary collaboration, nurtures scientific talent, and supports the next generation of innovators.

I actively engage with industry leaders, policymakers, and research institutions to shape the future of the life sciences ecosystem.

By participating in conferences, thought leadership activities, and industry forums, I strive to drive positive change and advance the boundaries of medical research.

I am always excited to speak with like-minded professionals, researchers, and individuals passionate about making a difference in healthcare. ⬇️

Let's amplify our impact in healthcare by connecting and collaborating towards a brighter future.🧑🏻‍🔬

Melanie Lee

Sunglass Hut

- Successfully balanced professional responsibilities with university studies, demonstrating strong time management, organization, and the ability to meet deadlines in both academic and work environments.
- Consistently exceeded personal and store KPIs by delivering tailored customer service and working as part of a team. 
- Demonstrated diligence in visual merchandising, high-end branding, and current fashion trends. 
- Competently operated Ciao! PoS system for all transactions. 
- Strictly complied with GDPR guidelines when handling customer data. 
- Showcased personal and emotional selling through high level of professionalism and close rapports with customers.

Sales Associate

As part of the Immuno-Oncology Alliance between LifeArc, CRUK and Ono Pharma, my project aimed to characterise the physicochemical properties of a lead monoclonal antibody candidate targeting an oncologic target. 
Over the course of the year, I cultivated a robust skill set in assay development and optimization, mastering techniques such as surface plasmon resonance, flow cytometry, SEC-MALS, and antibody titration assays. Exposure to these diverse laboratory techniques significantly advanced my technical expertise and problem-solving abilities, propelling my career forward. 
In addition, I have demonstrated competency and independence in molecular techniques, such as transfections, protein purification, ELISA, western blotting and others. With strict adherence to biocontainment and aseptic technique, I established various cells lines, from THP-1 and WTSli022 to CHOs and DAOYs. 
My roles also involved presenting my experimental analyses in monthly project team meetings, compiling an experimental report for lead characterisation pipeline, and providing support to lateral projects within the Motor Neurone Disease division.

Placement Student

MyTutor.co.uk

- Individualised A-Level and GCSE biology and chemistry curriculae based on unique learning styles and communication from forging close rapports with pupils. 
- Demonstrated reflection through logging student service feedback and worked in partnership with guardians to improve services. 
- Had a direct impact on pupils' well-being by complying with safeguarding policies, ensuring life-long learning and pupil satisfaction.

Online Tutor

Merck

My project focused on designing an outreach programme aimed at diversifying clinical trial cohorts to diminish ethnoracial inequalities within healthcare as part of MSD's Diversity & Inclusion portfolio. 
I developed a comprehensive understanding of existing ethnoracial disparities through extensive literature review of health economics, historical contexts and relevant legislature, and psycho-behavioural factors influencing perception and engagement with healthcare. 
We proposed an online hub containing culturally-sensitive information and translation services in clinical trial engagement, as well as recruiting trial dashboard to enhance engagement and encourage participation.

Project Intern

Vision Express

- Promoted a patient-centered approach in dispensing spectacles by providing comprehensive consultations on eye health, lifestyle, and budgetary considerations.
- Demonstrated timeliness and efficiency while ensuring accuracy and compassionate care during optometric screenings and health surveys. 
- Fostered multidisciplinary operations between optical dispensers, lab technicians and optometrists to provide an individualised care plan. 
- Proficiently managed patient queries and referrals, and actively accommodated vulnerable groups, including patients with disabilities, late and early years.

Optical Assistant

University Hospital of Walsgrave Coventry

- Gained nuanced insight into multidisciplinary operations across microbiology, cytology, immunology and biochemistry, to provide holistic, efficient and patient-centred care by shadowing scientists from these diverse expertise. Importantly, 
- Acquired technical competence in common analytical techniques, including HLA typing, histology, viral typing and haematology analysers. 
- Fostered a deep understanding of the vital collaboration between laboratory and clinical teams in reviewing clinical and molecular diagnostics, driving treatment decisions, and ensuring thorough audit trails for optimal patient care.

Pathology Laboratory Work Experience

Diligent molecular biology student at the University of Sheffield with strong expertise in immuno-oncology. Experienced in both industry and academia, having interned at LifeArc (Stevenage) and NanOncolytics lab (Sheffield), focusing on translational and collaborative research. Currently completing my Master's project under the supervision of Professor Munitta Muthana, developing and characterising a panel of bio-compatible nanoparticles for targeted epirubicin delivery in breast cancer treatment.

taplio

The Battle

Melanie Lee

Daniel Ludwikowski

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