The Open University

Lecturer

University of Birmingham

Research Fellow

Universiteit Maastricht

I was working as a Senior Postdoctoral fellow in the department of Cardiac Thoracic Surgery at Maastricht University, carrying out research aimed at improving patient health by developing novel  ventricular assist devices as well as improving detection capabilities and ablation techniques in the field of atrial fibrillation

Senior Postdoctoral Fellow

KU Leuven

FWO Postdoctoral Research Fellow

Bio-Plus Safety Pharmacology

Bio-Plus Safety Pharmacology was a contract research organization providing fast, flexible and standardized solutions in the field of non-clinical cardiovascular safety (CVS) pharmacology. During my time at Bio-Plus I was involved in novel model validation as well as business development and writing of SOPs and scientific literature

Project Leader Safety Pharmacology

Maastricht University

Over the last decades, drug induced cardiac arrhythmias, including Torsades de Pointes (TdP) have become a major issue in drug development. There is a pressing need for better understanding of the mechanisms involved in TdP manifestation to allow for enhanced prediction (via more predictive surrogate markers) and prevention of this arrhythmia (via novel targets). This thesis elucidates a number of cellular mechanisms involved in beat-to-beat variability of repolarization, which is one of the newer surrogate markers thought to have utility in predicting this arrhythmia. The thesis highlights the role of calcium release from the calcium store within the single myocyte in altering this parameter. Additionally the dissertation illustrates the link between mechanical and electrical activity under specific conditions and provides further validation of an additional novel marker for proarrhythmia (the electro-mechanical window). Finally, research contained within this thesis suggests antiarrhythmic strategies for the development of novel therapeutic agents.

PhD Student

Merck Sharp & Dohme

During this period i worked in the neuroscience research centre,working on various projects, including TRPV1 channels  using various electrophysiological techniques, such as patch clamp recordings in both native tissue and transfected cells

Staff Biologist

Specialties: QT Prolongation; Beat-to-beat Variability of Repolarization; Arrhythmogenesis; Calcium Handling; Cardiovascular Safety Pharmacology; Patch Clamp; In-vivo screening; Electrophysiology; Atrial Fibrillation

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