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Gabrielle M. Siegers

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I am delighted to continue putting my knowledge and skills to work fighting cancer at Helix BioPharma! I obtained my PhD at the Max Planck Institute for Immunobiology, where I defined the stoichiometry of murine and human γδ T cell antigen receptors. I returned to Canada to join Dr. Armand Keating’s translational laboratory at the Princess Margaret Hospital (Toronto, Canada) where I developed a bioluminescent xenograft mouse model of Philadelphia-chromosome-positive (Ph+) leukemia to test γδ T cell immunotherapy. I also discovered that γδ T cell subsets differentially target Ph+ and B cell chronic lymphocytic leukemias. In the laboratory of Dr. Paula Foster at Robarts Research Institute (London, ON, Canada), I devised a procedure to expand primary human γδ T cells for labeling with iron-oxide nanoparticles and tracking in preclinical cancer models via MRI, confirming their anti-cancer functions against prostate and brain cancer cells. I then joined the laboratory of Dr. Lynne-Marie Postovit to study how the breast tumour microenvironment impacts γδ T cell function. With my former PhD student, Indrani Dutta, I explored tumour escape mechanisms employed by breast cancer stem-like cells and how to enhance γδ T cell targeting of this rare yet critical population. I also began investigating the potential of γδ T cells to target ovarian cancers. I have been privileged to give invited talks on my research to lay and scientific audiences at national and international meetings in Canada, the United States and Germany. The link to my publications on PubMed is: http://www.ncbi.nlm.nih.gov/pubmed?term=Siegers%20GM

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