Ryvu Therapeutics

Chief Information Officer

AstraZeneca

- Led a multi-national, Oncology small molecule discovery/pre/clinical informatics team of 20+ across three geographies
- Defined a computational strategy for the AstraZeneca-CRUK Functional Genomics Centre, building relationships and gaining senior endorsement, laying groundwork for new combination drug targets entering AZ Oncology portfolio
- Improved revenue forecasting of new products using real world molecular diagnostic testing rate data
- Developed a leadership coaching programme to prepare the next generation of leaders and create high performing, successful teams
- Mentored innovative, industry disrupting biotech startups via the AstraZeneca Exchange Programme, supporting collaborative networking across the Life Sciences. Partnered with a Cambridge accelerator, StartCodon, acting as a bridge between technology and business in AstraZeneca

Senior Director, Data Science

Cambridge Epigenetix

Led the end-to-end, sample to insights machine learning product development for circulating epigenetic biomarkers. Molecular diagnostic development in a regulated environment.

Director of Data Science and Bioinformatics

Associate Director Bioinformatics, Precision Medicine and Genomics at AstraZeneca. Focus on molecular diagnostics especially for point of care.

Associate Director Bioinformatics, Precision Medicine and Genomics

Oncology Translational Science informatics & stats lead (UK). Analytics and algorithm development for the analysis of genomic data with focus on next generation sequencing and biomarker discovery. Training and mentoring of colleagues in the use of novel algorithms. Innovation with external collaborators.

Associate Principal Informatics Scientist, Oncology Translational Science

Big Data Analytics, with emphasis on personalised healthcare and oncology. Working with and developing scalable open source platforms for next generation sequencing data analysis (RNA-Seq, DNA-Seq) in biomarker research.

Associate Principal Informatics Scientist, R&D Information

Almac Group

Developed a product for machine learning based biomarker discovery. Consulting for big pharma customers in biomarker discovery and validation in immunology and oncology. Mentored, coached and trained junior analysts.

Senior Bioinformatics Scientist

University of Leipzig, IMISE

Alexander von Humboldt postdoctoral fellow

Postdoctoral fellow, Machine learning

Tampere University of Technology

Doctoral Research Scientist in Computer Science

Institute for Systems Biology

Visiting researcher

CIO at Ryvu Therapeutics. Biotech & pharma experience since 2009. Cambridge Judge Business School Executive MBA 2023. PMP Certified.
- Leading a team delivering data-based insights to move the needle in all stages from new target discovery through preclinical to the clinic in oncology
- For MBA individual project bridged commercial strategy and R&D by improving clinical trial investment decision governance through incorporating companion diagnostic testing rate data in forecasting 2022. 

Organiser of: https://www.meetup.com/Cambridge-UK-Computational-Biology-Bioinformatics-Meetup/
ORCID: https://orcid.org/0000-0002-9091-7773
Code: https://github.com/mjafin
Advisor at: https://aicap.services/

Key words: Leadership agility, Stakeholder Engagement, Analytics, Insights, Biomarkers, Diagnostics, Informatics strategy, Innovation, Data, Machine learning, Oncology, PMP, clinical.

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