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Rebekah Byford

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I am currently a Group Leader / Associate Principal Scientist within the Characterisation team, part of Development Services, at Lonza Biologics. Prior to this I was a Lead Scientist, Study Director and Supervisor working with Reference Standards for both GMP drug product and drug substance. My role involved: -- Study directing stages within the team to help prepare, qualify and characterise reference standard for GMP testing on time, perform biochemical comparability studies and review the related regulatory submission sections. -- Supervising two direct reports (regular 1-2-1 meetings, probation review, scheduling work, attending L1 management meetings). -- Liasing with customers as an Analytical representative & Study Director. -- Performing analytical assays (HPLC, CE SDS, icIEF, N-linked oligosaccharide profiling & reduced PMAP-MS). -- Technical review (reduced PMAP-MS). This role builds on the foundation I gained during my placement year at Bristol-Myers Squibb and multiple work experiences with Shire Pharmaceuticals. Prior to that, I passed my PhD viva with minor corrections. The thesis research looked into Ferritin Nanocages for High-Throughput protein recognition. During my PhD I researched a novel engineered ferritin nanocage for its use in a biosensor to replace traditional techniques like ELISA. A combination of techniques were used to further understand the protein (HPLC SEC, Nanosight (nanoparticle tracking analysis), Fluorescence Correlation Spectroscopy, Total Internal Reflection Fluorescence Microscopy and Transmission Electron Microscopy); requiring multiple redesigns. Alongside this early proof of concept of the proposed device was studied with lysozyme and nanopipettes.

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