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Sanjeev Thohan

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Sanjeev Thohan is a highly motivated research scientist who with every move has sought new challenges to overcome. He holds MS and PhD degrees in Pharmacology and Toxicology with concentrations in drug metabolism mechanisms, bioactivation pathways, and systems toxicology. He has actively contributed to: preparation of Pre-IND/IND, NDA and proof of concept documentation to support regulatory filings as preclinical development continues; inter-species scaling and projection of FIM dosage algorithm development; metabolic pathway elucidation and structural (SAR) feedback to medicinal chemistry for additional iterations based on biological data streams; high throughput bioanalytical method development/transfer, as well as troubleshooting for rapid method development/implementation. He has also led teams for evaluation of strategic critical pathway development, implementation and execution to provide data front-loading and reduction in time to IND. He is a highly motivated research scientist who has worked at Walter Reed Army Institute for Research, Covance Laboratories, AstraZeneca, Viropharma, Exelixis and as the founder of SARx Consulting it Novartis (NIBR), Xeris Pharmaceuticals, Kinnate Biopharma and is currently SARx consulting in San Diego assuring and mentoring startups. Sanjeev’s track record includes advancement of 42 small molecule compounds through discovery to IND and various stages of active clinical development since 1997 with 7 of these progressing to NDA/Market. Therapeutic areas in which he has been actively involved are oncology, cardiovascular, metabolic diseases and antimicrobial, as well as antiviral therapeutics. Sanjeev continues to be a contributing member of several national/international scientific societies. He is a very active speaker with local and national scientific groups regarding preclinical safety/Mechanistic Toxicology, ADME-PKPD relationships and translational sciences. He actively serves on the advisory boards for several startups and is involved in mentoring new startups and investigators to seed the next generation for growth.

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