BeiGene

Delivering validated IT infrastructure, plant automation systems (DCS,EMS,BAS, PI Historian), Maximo CMMS, and clinical lab systems at the Hopewell, NJ greenfield Modular DS/DP site.

Features:
OT DLR Network design; Redundant server clusters; AWS for Historian and file storage; AD enabled OT systems; IT SOPs

Director, Manufacturing Systems

Xellia Pharmaceuticals

Led Xellia Digital Factory program to improve Quality, Manufacturing performance and Tech transfers. Digital Vision and Agile Strategy based on Pharma 4.0 developed and governed by global core team. Site level assessments provided 3-year project road maps. On Phase1, Site teams were engaged in Level 0-2 projects. Corporate standards / Global apps were developed and used.
• Plant Connectivity: Global Process Network in place to connect assets, to process Historian data and to improve asset life cycle. IEC 62443 based Assessment used to build plans.
• Level 0/1 hardware and software Standards were established at the site level to simplify and improve engineering, to improve operations tech support and establish asset life cycle process.
• Validated Historians completed. Unified Naming Convention adopted for new filling lines.
• Global computer system validation using Micro Focus ALM process has had been established.  Overall validation effort had been reduced by 60%
• E-Log books pilot completed for Cleveland filling lines. Site team optimized Logbooks and created data stream mapping. Pilot EBR assessment was completed.
• Stood up an Analytical team to build our first Continuous Process Validation dashboard using data from Historians, LIMS, and ERP systems. Our pilot for our API lines finished user acceptance testing.
• Pharma 4.0 requirements and specification templates were created. User requirements, Installation and Validation process for 2 new RTU fill Lines (Cleveland) and 1 Vial fill line (Copenhagen) were based on these standards. Worked with Project management vendor and OEM vendors in the procurement, design, installation, and validation of these 3 New lines.
• Cloud-based, Out-of-the-box, configured solutions and IIOT were used to accelerate adoption and to reduce development times and costs.

Director Global Engineering, Automation and Manufacturing Systems

Sanofi

Site Leader for I4.0 Strategy and Roadmap for Sanofi's largest ($3B) Vaccine site. Partnered with Site Cross Functional partners to build digital roadmap for the Swiftwater, PA site. Worked with Global Digital Team to harmonize site plans, business goals and corporate mandates. Recruited and built the site Pharma 4.0 cross functional team (6) consisting of PM’s, ERP SME’s, Data scientists and engineers. My experience in aerospace and automotive helped to accelerate the Pharma 4.0 program adoption.
• Site assessments were done using the Sanofi version of Digital Plant Maturity Model (DPMM).
• A 3-Year Site Digital Roadmap and resource requirement was developed and approved. 
Following Digital projects launched, and progress monitored using a Digital Credit scoring system:
• Piloted an EBR for a new Seed manufacturing building based on EIS Opstrakker tool.
• Implemented AWS based Plant Control Tower to improve supply chain visibility, Deviation Intelligence (ML) tool to facilitate deviations closing.
• OEE Automation/Targeted actions improved Vaccine filling OEE by 3% on 3 filling lines.
• Digital team produced 36 self-paced VR/MR Training modules to improve on-boarding of a new Biologics building. A Delta-V Simulated training system was also produced for this project.
• Fill-Finish capacity model was developed using Rockwell Arena to develop COVID-19 Fill strategy.
• Digital Team was stood up to start a MES implementation based on Siemens Simatic IT.
• Digital Team representative for all site capital projects ($400M) involving:
	o Plant Connectivity, Automation specification o Data Standard, Data Lake integration
	o EBR, MES
• Installed IIOT Vibration monitoring system from Augury on AHU’s to improve reliability.
• Sponsored a ML yield optimization intern project to improve Egg supply yield.
• Partnered with Quartic.ai to pilot Operations Intelligence tool for the biologics building.

Site Lead Digital Transformation, Pharma 4.0

Arconic

Led the Smart Manufacturing (SM) Vision, Strategy, and road maps at aerospace parts maker Arconic.  Corporate Governance, Digital Standards, Roles and Responsibilities were developed and enforced. Conducted SM Workshops at Plant levels to create awareness and facilitated development of Digital Road maps. Corporate evaluator, approver for Physical (Robots/Material Handling/Equipment Upgrades) and Digital (MES, Scada, Historian) projects. 
•	Created Process/Equipment Capability and Performance analysis. Deployed Machine Learning Tools to optimize manufacturing capacity and predictive analysis for Heat treat Furnaces and forge presses.
•	Evaluated suppliers, products, technology to create dynamic corporate standards
•	Assembled a corporate Digital surge team to improve plant performances on a 90day deployment. The Team visited distressed sites to facilitate turn around plans. A Digital Toolbox was developed to collect KPI’s/Quality data to improve turnarounds.

Corporate Digital Transformation Lead

Leader of the Industry 4.0 Strategy. Convenor of Business unit Smart manufacturing Steering team with IT, Quality and Capex directors.  Owner of Governance, Standards, Apps/Tools and Capital Projects. 
Conducted SM Workshops at Plant levels to create awareness and facilitated development of Digital roadmaps. BU approver for Physical (Robots/Material Handling/Equipment Upgrades) and Digital (MES, Scada, Historian) projects 
✸ 3-Year Road Maps and project plans for Physical and Digital Automation of 3 plants in the US launched
✸ Created Process/Equipment Capability and Performance analysis. Deployed Machine Learning Tools to optimize manufacturing capacity and predictive analysis for Heat treat Furnaces and forge presses.

Business Unit Smart Manufacturing Technology Manager

Assessed and Created Automation Vision, Strategy for the Alcoa/Arconic Cleveland Works.  Stood up the site automation team.
•	5-year Process Control systems upgrade strategy was instituted. Level1 hardware and software standardization improved process control; reduced Engineering development and validation.
•	Created the Smart Manufacturing Road Map. Implemented a new Level2 architecture and a network to improve Security. Virtualized all Plant computer Systems.
•	Process Historian was standardized and Operational KPI and Process data report portal was created
•	Converted paper-based Product inspections into web based, IIOT enabled automated systems
•	Piloted a Track and trace system using Ignition package for Jet engine blade line
•       𝗠𝗮𝗻𝗮𝗴𝗲𝗱/𝗣𝗮𝗿𝘁𝗶𝗰𝗶𝗽𝗮𝘁𝗲𝗱 𝗶𝗻 𝗮𝗹𝗹 𝗰𝗮𝗽𝗶𝘁𝗮𝗹 𝗽𝗿𝗼𝗷𝗲𝗰𝘁𝘀 (~$𝟭𝟬 𝗠𝗶𝗹𝗹𝗶𝗼𝗻/𝘆𝗲𝗮𝗿) 𝗨𝗽𝗴𝗿𝗮𝗱𝗶𝗻𝗴 𝗙𝘂𝗿𝗻𝗮𝗰𝗲𝘀/𝗣𝗿𝗲𝘀𝘀/𝗨𝘁𝗶𝗹𝗶𝘁𝘆 𝘀𝘆𝘀𝘁𝗲𝗺𝘀. 𝗗𝗲𝘃𝗲𝗹𝗼𝗽𝗲𝗱 𝗮𝗻𝗱 𝗜𝗻𝘀𝘁𝗮𝗹𝗹𝗲𝗱 𝗮 $𝟰.𝟮𝗠, 𝟭𝟬 𝗧𝗼𝗻 𝗖𝘂𝘀𝘁𝗼𝗺 𝗥𝗼𝗯𝗼𝘁𝗶𝗰 𝗠𝗮𝗻𝗶𝗽𝘂𝗹𝗮𝘁𝗼𝗿 𝘀𝘆𝘀𝘁𝗲𝗺 𝗳𝗼𝗿 𝗜𝗻𝗴𝗼𝘁 𝗳𝗼𝗿𝗴𝗶𝗻𝗴
•       𝗜𝗻𝘀𝘁𝗮𝗹𝗹𝗲𝗱 𝗻𝗲𝘄 𝗥𝗼𝗯𝗼𝘁𝗶𝗰 𝗶𝗻𝘀𝗽𝗲𝗰𝘁𝗶𝗼𝗻 𝗰𝗲𝗹𝗹𝘀, 𝗙𝗮𝗿𝗼 𝟯𝗗 𝗟𝗮𝘀𝗲𝗿 𝘀𝗰𝗮𝗻𝗻𝗲𝗿𝘀, 𝗨𝗹𝘁𝗿𝗮𝘀𝗼𝗻𝗶𝗰 𝗜𝗻𝘀𝗽𝗲𝗰𝘁𝗶𝗼𝗻 𝗖𝗲𝗹𝗹𝘀 𝘁𝗼 𝗿𝗲𝗱𝘂𝗰𝗲 𝗰𝘆𝗰𝗹𝗲 𝘁𝗶𝗺𝗲 𝗮𝗻𝗱 𝗰𝗮𝗽𝘁𝘂𝗿𝗲 𝗽𝗿𝗼𝗱𝘂𝗰𝘁 𝗱𝗮𝘁𝗮 𝗳𝗼𝗿 𝗿𝗲𝗮𝗹 𝘁𝗶𝗺𝗲 𝗰𝗹𝗼𝘀𝗲𝗱 𝗹𝗼𝗼𝗽 𝗳𝗲𝗲𝗱𝗯𝗮𝗰𝗸
•	Our team effort using Kaizen events, Automation, Run-to-Recipe, Historian, OEE tracking on a Jet Engine Blade Flow-path resulted in 20% overall OEE improvement.

Site Automation Manager

With over a decade of experience in leading digital transformation and industry 4.0 implementation in the life sciences and pharma industry, I am currently the Director of Manufacturing Systems at BeiGene, a global biotechnology company focused on developing innovative cancer treatments. I hold a certification in Smart Manufacturing Leadership from MIT, which equips me with the skills and knowledge to create and manage digital factories and processes.

In my current role, I am responsible for delivering validated IT infrastructure, plant automation systems, and lab systems at a greenfield modular DS/DP site in the Princeton area. I leverage my IT and engineering expertise to design and deploy OT network, server clusters, AWS storage, and AD enabled OT systems. I also partner with cross-functional teams to build and execute the digital strategy and roadmap for the site, based on the Pharma 4.0 framework and best practices. My mission is to enable data-driven and agile manufacturing operations that deliver high-quality and cost-effective products to patients.

Taplio

Sridhar Ramasamy's Linkedin Analytics

Sridhar Ramasamy

Want to drive more opportunities from LinkedIn?

Taplio

.css-1jgreyo{background-image:linear-gradient(284deg, rgba(39,43,72,1) 0%, rgba(33,47,183,1) 100%);color:transparent;-webkit-background-clip:text;background-clip:text;}Sridhar Ramasamy's Linkedin Analytics

Sridhar Ramasamy

Want to drive more opportunities from LinkedIn?

Sridhar Ramasamy's Linkedin Analytics