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Umbereen S. Nehal, MD, MPH, MBA

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Dr. Nehal is a founder of a digital health venture incubated at MIT, inspired by her own patient journey and the stories of over 200 women. Her team is designing an AI-enabled FemTech solution to improve women’s health for common conditions like fibroids, menopause, endometriosis, and pelvic pain. As an MIT Sloan Fellow with additional coursework via Stanford LEAD, Dr. Nehal has honed skills in AI-enabled big data analytics and human-centered design for healthcare. A seasoned physician executive, a former Chief Medical Officer for 14 centers, a co-author of $1.8b in Medicaid value-based care reform, Dr. Nehal is skilled at public-private partnerships to advance cross-sector solutions for population health. She is a keynote speaker and was recognized by President Obama for her community organizing in marginalized communities. She is focused on systems approaches for improved health and wellbeing outcomes. See below are some more details on her work. **** Domains of work: ➡️Consulting Founder of healthcare consulting firm with services in assessment of new technology for clinical/cost effectiveness, quality improvement, program evaluation, clinician engagement, community partnership, change management, coaching, & personal brand. ➡️Medical Affairs leadership: -Former Medicaid medical director with deep expertise in value-based care and delivery system transformation, clinical lead on $1.8b DSRIP design. -Former Chief Medical Officer & VP of Medical Affairs of multi-specialty, multi-site practice setting, a certified Patient Centered Medical Home with integrated behavioral health, dental, vision, and specialty care. Responsible for compliance for quality of care, operational excellence, cost targets, population health, and change management for whole-person care to improve outcomes, patient experience, affordability, equity, and access. -Former Chair of Provider Review Committee for the Commonwealth of Massachusetts ensuring compliance with standards and protecting patient rights. -Former Chair of IRB ensuring research ethics and safety. ➡️Communication: Keynote speaker and a four time LinkedIn “Top Voice” and invited to speak on social media in STEM and for physicians. Led grassroots campaigns in marginalized communities on behalf of White House and HHS. Advisor to federal and state agencies. ➡️Medical Education Physician leader who has co-authored national ACGME compliant curriculum and contributed to two state public health curricula. Published refugee health curriculum in an open access journal. Sloan Fellow

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Umbereen S. Nehal, MD, MPH, MBA's Best Posts (last 30 days)

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“…men who reported high levels of childhood stress had different epigenetic profiles in their sperm compared to those who reported lower stress. These differences persisted even after accounting for other factors like smoking and drinking, suggesting that childhood experiences can leave lasting epigenetic marks.”

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A new study shows that a father's stress leaves lasting marks on his sperm — influencing the development of his offspring. This new research, published in the journal Molecular Psychiatry, delves into the field of epigenetics, which explores how environmental factors can alter gene expression without changing the underlying DNA sequence. These epigenetic changes can act as molecular switches, turning genes on or off and influencing various biological processes. Researchers analyzed sperm samples from 58 men, most in their late 30s to early 40s. The study revealed that men who reported high levels of childhood stress had different epigenetic profiles in their sperm compared to those who reported lower stress. These differences persisted even after accounting for other factors like smoking and drinking, suggesting that childhood experiences can leave lasting epigenetic marks. The researchers also found differences in a specific small noncoding RNA molecule previously linked to brain development in mice, as well as variations in DNA methylation patterns near genes involved in early brain development. While these findings suggest a potential link between childhood stress and epigenetic changes in sperm that could influence offspring development, it's crucial to emphasize that this research is still preliminary. It's not yet confirmed whether these epigenetic changes are passed down to children or what their ultimate impact might be. Further research is needed to determine the extent to which these epigenetic modifications in sperm can affect the health and development of future generations.


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